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Process Development & Optimization
Employing scaleable and representative unit operations, we offer custom development of client processes from preliminary research findings to development of robust upstream and downstream processes.
Our efforts include:
- Assessment of process feasibility and amenability to scale-up
- Optimization of appropriate steps in the process
- Process design to minimize scale-up issues and yield
Process Development - upstream
Microbial fermentation process development, optimization and scale-up:
- Batch
- Fed-Batch
Mammalian cell culture process development, optimization and scale-up:
- Batch
- Fed-batch
- Perfusion
Process Development – downstream
- Purification process development, optimization and scale-up:
- Initial recovery and clarification
- Chromatography purification
- Membrane filtration
- Tangential Flow Filtration (UF/DF)
- Viral inactivation and clearance
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