eADME/T& PK Studies

We offer a broad portfolio of in vitro assays that enable evaluation of critical ADME/T parameters for pharmaceutical drug discovery.

Aqueous Solubility

Measurement of compound solubility in buffers at different pHs

Permeability

Evaluation of compound permeability across biomembranes using either PAMPA (non-cell based) or Caco-2 and MDCK (cell-based)

CYP450 Inhibition

Determination of inhibition of CYP450 enzymes (3A4, 2D6 & 2C9) by compounds in fluorimetric assays

pH & Metabolic Stability

Evaluation of compound stability in various pH conditions or after incubation with liver microsomes from multiple species

Plasma Protein Binding

Measurement of binding of compound to blood plasma protein

Cytotoxicity

Evaluation of compounds for toxicity in cell proliferation or viability assays using appropriate cell lines