10+ years, latest 2-3 years HR-generalist experience and exposure to global multicultural settings, preferably in life sciences R&D environment

• Lead the Human Resource Management function at BBRC, including Recruitment, Compensation and Benefits, and Learning and Development; shaping evolution of HR policies
• Responsible for Strategic HRM advisor to the BBRC site head.
• Successful candidate will be a member of the BBRC Senior Leadership Team

Responsibilities of the selected candidate at various positions will include - Independently designing, analyzing and interpreting experiments. Ablity to troubleshoot, recognize technological limitations, conduct thorough background search on a problem, keep up with literature and new developments in relevant areas, attend scientific meetings and training workshops.

The candidate will also be expected to evaluate and implement new ideas, contribute to decision making, take informed scientific risks, write technical documents and/or research articles, communicate own scientific achievements both internally and externally.

Responsibilities of the selected candidate at various positions will include the timely design of safe, expedient and efficient chemical routes and processes for the synthesis of targeted pharmaceutical intermediates and drug candidates. The candidate will also be responsible for the scale-up of these processes to kilo scale and for transitioning such processes to larger scale-up facilities such as pilot plants.

The selected candidate will be a part of and/or lead a number of scientists in the Metabolism and Pharmacokinetics  (MAP) group, focused on non-clinical pharmacokinetic and metabolism of new chemical entities, in support of various drug discovery programs. Depending on the position, he/she will design and conduct appropriate in vivo or in vitro ADME studies, represent the department at various discovery working group meetings, suggest and implement strategies and tactics to address PK/PD/ADME related issues and ultimately enable program decision-making in the selection and advancement of high-quality drug candidates from discovery to development. The incumbent will collaborate with a broad group of scientists across various disciplines in the discovery organization.

5-9 years of experience in IHC in molecular path lab

Responsibilities of the selected candidate is to develop and validate biomarker assays by IHC, image analysis and validation of analysis methodology, calibration and maintenance of equipment with proper documentation and to supervise all types of procedures such as accessioning, processing, embedding, cutting and staining of tissue slides.

The successful candidate has to supervise preparation and maintenance of reagents and supplies and also be responsible for quality control, assay trouble-shooting, review and approval of clinical data. The key personnel should oversee the study from the beginning to the end.

Principal Investigator/Sr. Principal Investigator for Metabolic Disorder, Cardiovascular, Behavior Neuroscience areas In Vivo Pharmacology/Biology

PhD in Pharmacology/Biochemistry with expertise in one or more of the following areas:
Metabolic Disorder and/or Cardiovascular Biology, Neuroscience and Pain/ Behavioral Pharmacology

0-5 years of post-doctoral experience along with minimum 3-6 years of relevant Industry experience in Drug Discovery.    

Successful candidate will be responsible for setting up a team of 8-12 PhD and Master level scientists,and would assume responsibility for the completion of studies in multiple therapeutic areas.

The individual would be part of the discovery working groups and work with project leaders from different functions to coordinate study designs, implementation and reporting.

Research Associate /Sr Research Associate - In Vivo Biology/Pharmacology

MS/MPharm/MVSc or equivalent Master’s Degree in one of the following areas: Physiology, Neuroscience, Behavioral Pharmacology, Metabolic Disorder (Diabetes, Obesity), Cardiovascular Pharmacology, Immunology, Oncology

0-5 years of research experience from a drug discovery based Pharmaceutical company or Academic Institute

The successful candidate(s) will be part of the discovery programs and be responsible for the implementation and completion of in vivo efficacy studies to assess drug action in multiple therapeutic areas.

The individual will be responsible for experimental planning, data analysis, interpretation and presentation of data and report submission.

Research Associate/Sr. Research Associate – Biology

M.V.Sc in Veterinary Pathology

Minimum 2-5 years of experience in drug discovery research.

The candidate will be part of in vivo Biology team providing pathology support for discovery biology programs.  Selected candidate will also interface with Toxicology and DMCP scientists and contribute to the overall success of the Discovery team.

• The candidates will be part of our team of drug discovery scientists involved in lead identification and optimization.
• Primary responsibilities would include independent design, synthesis, purification and characterization of novel small molecules. Strong working knowledge of synthetic organic chemistry including multi-step synthesis and a thorough.

• The successful candidate should have experience in electrophysiology either in academics or in research work.
• Hands on experience in working with ePhysics set up and recording and data analysis.

• Successful candidate will be responsible for supporting/leading electrophysiology requirements for various drug discovery programmes.
• Demonstrate excellent understanding of Biology, Pharmacology and pathophysiology in one or multiple disease area.
• Highly competent in multiple technical aspects relevant to own disease area discovery biology.
• Understands the competitive environment and its implications regarding meeting our goals.
• Should possess good management, excellent written and oral communication skills. Ability to interact with multi-disciplinary drug discovery teams and contribute to teamwork and teambuilding.
• Effectively weighs risks, costs and benefits to make rational, objective decisions.
• Plans, drives and organizes projects in order to achieve goals. Resourceful and foresees hurdles and plans appropriately.
• Prior working experience in Industrial Drug Discovery is desirable.

• The ideal candidate should be a MS level Biophysicist with thorough knowledge of macromolecular crystallization and characterization of protein-ligand interactions using different biophysical techniques like DLS and ITC.
• Knowledge and experience of expression & purification of protein will be advantageous.

• Successful candidate will be responsible for setting up a team of 8-12 Ph.D. and Master level scientists. Would assume responsibility for the completion of studies in multiple therapeutic areas.
• The individual would be part of the discovery working groups and work with project leaders from different functions to coordinate study designs, implementation and reporting.

• The candidate must have training as an in vivo Pharmacologist/Biologist with drug discovery experience in one or more of the following therapeutic areas: Neuroscience and Pain/Behavioral Pharmacology.
• Demonstrate excellent understanding of Biology, Pharmacology and pathophysiology in one or multiple disease area. Demonstrates knowledge/ expertise within and outside own disease area.

• Highly competent in multiple technical aspects relevant to own disease area discovery biology.
• Understands the competitive environment and its implications regarding meeting our goals.
• Should possess good management, excellent written and oral communication skills. Ability to interact with multi-disciplinary drug discovery teams and contribute to teamwork and teambuilding.
• Effectively weighs risks, costs and benefits to make rational, objective decisions.
• Plans, drives and organizes projects in order to achieve goals. Resourceful and foresees hurdles and plans appropriately.
• Prior working experience in Industrial Drug Discovery is desirable.
  
  

• With expert knowledge of Analytical Chemistry and Separation Sciences capable of directing all activities of the Analytical Research and Development in support of Synthesis and Process development and Bio-pharmaceutical support. 
• Think independently and lead a group of analytical scientists responsible for day to day analytical activities including process scale-up, GLP and GMP, development and validation of methods in support of manufacturing process development of intermediates and APIs. 
• Responsible for integrating the scientific work of others and provides input on experimental design, data analysis and interpretation.

Effective troubleshooter of procedures and instruments;
Provides solutions, alternatives, and answers to difficult situations;
Has a solid fundamental knowledge of separations (e.g. understands multiple factors affecting separation speed);
In-depth expertise in one or more specialty areas, e.g. chiral separations; 
Knowledge of chromatographic techniques which are interfaced to MS instruments utilized within department (e.g. LC, GC, CE, SPE, etc); 
Provides innovative analytical solutions and ability to recognize context of scientific endeavors; Demonstrates broader understanding of analytical chemistry, and other areas of chemistry relevant to drug development, e.g. organic, physical chemistry;
Excellent communication skills and the ability to motivate team members in a fast paced environment.

• Expert knowledge of Analytical Chemistry and Separation Sciences capable of directing and co-coordinating all activities of the Analytical Research and Development in support of Synthesis and Process development and Bio-pharmaceutical support. 
• Independently lead a group of analytical scientists responsible for day to day analytical activities including process scale-up, GLP and GMP, development, and validation of methods in support of manufacturing process development of intermediates and APIs. 
• Responsible for integrating the scientific work of others and provides input on experimental design, data analysis and interpretation.

Effective troubleshooter of procedures and instruments;
Provides solutions, alternatives, and answers to difficult situations;
Has a solid fundamental knowledge of separations (e.g. understands multiple factors affecting separation speed);
In-depth expertise in one or more specialty areas, e.g. chiral separations; 
Knowledge of chromatographic techniques which are interfaced to MS instruments utilized within department (e.g. LC, GC, CE, SPE, etc); 
Provides innovative analytical solutions and ability to recognize context of scientific endeavors; Demonstrates broader understanding of analytical chemistry, and other areas of chemistry relevant to drug development, e.g. organic, physical chemistry;
Excellent communication skills and the ability to motivate team members in a fast paced environment.

• To provide scientific and technical support/guidance to activities involved in identifying developable drug candidates, form selection, physicochemical characterization of new drug candidates, and development of toxicology and Phase I clinical formulations. 
• To identifies the best formulation strategy for rapidly and successfully moving a new compound into Phase I clinical testing and enabling first-in-human formulation production by clinical supplies organization (or third party manufacturer). 
• To provide coaching and personal development opportunities to staff in scientific as well as managerial areas. 

Knowledge of basic chemistry and pharmaceutical principles in understanding the physicochemical properties of new drug entities and how they relate to the drug’s ultimate in vivo disposition. Hands on experience with routine analytical instrumentation, such as HPLC, DSC, TGA, UV spectrophotometer, etc., and experience with physicochemical characterization and formulation development are desired. Ability to independently plan, design, implement and summarize research experiments and provide scientific leadership. Excellent written and oral communications as well as having good interpersonal skills and the ability to work with teams in a dynamic environment are essential. Hands on computer skills and knowledge of statistics for experimental design and data treatment are important.

Research Investigator/ Sr. Research Investigator - Biopharmaceutics

• Key responsibilities include API solid form screening (polymorph and counterion), crystallization, characterization, evaluation of the physical/chemical and thermodynamic stability of crystalline forms. 
• Design and implement safe, efficient and robust isolation/purification processes for API and key intermediates. 
• Participate in the scale-up and delivery of toxicology or clinical trial materials. Work with a broad range of molecules, including APIs and synthesis intermediates, small molecules and sometimes semi-biologic molecules (peptides), in close collaboration with chemical development, drug product and analytical development teams.   
  
  

• Candidates must possess excellent problem solving skills with a strong background in theory and practice of solid form characterization, isolation/purification techniques, organic chemistry, thermodynamics, and analytical tools. 
• Experience with API solid form selection, chemical development, and crystallization technology is highly desired.  Additional experience in non-conventional separation techniques, such as lyophilization, spray drying, and/or other novel isolation technique is advantageous.  Ability to lead multi-disciplinary teams is desirable. 
• Candidate is expected to have knowledge of solid characterization techniques such as DSC, TGA, XRD, optical microscopy, Lasentec FBRM/PVM, Raman, SEM, and BET surface area.
• Candidate is also expected to reproduce and scale up any specific solid forms that emerge after, form screening efforts and develop a feasible crystallization process that is aligned with chemical development. 
• An excellent verbal and written communication skill with the ability to provide technical input and scientific leadership is required.
  
  

Senior Research Investigator / Principal Investigator - Discovery Metabolism and Pharmacokinetics (MAP)
Pharmaceutical Candidate Optimization (PCO)

The major responsibility of the selected candidate will be to lead the MAP group, focused on nonclinical pharmacokinetic and metabolism of new chemical entities, in support of various drug discovery programs. He/she will represent the department at all site meetings, and discovery working group meetings, suggest and implement strategies and tactics to address PK/PD/ADME related issues and ultimately enable program decision-making in the selection and advancement of high-quality drug candidates from discovery into development. The incumbent will collaborate with a broad group of scientists in the various PCO department, as well as scientists across various disciplines in the Discovery organization. The individual will play a major role in setting group strategy, vision, and take a lead in key scientific initiatives.

Hands-on experience and in-depth training in the areas of nonclinical pharmacokinetics (PK), pharmaco-dynamics (PD) and/or drug metabolism are required. These include, but not limited to, PK and PK/PD study design and data analysis, drug metabolism concepts and assays, enzyme kinetics, etc. Hands-on experience in conducting in vitro and in vivo studies to assess the ADME of discovery compounds (cell culture, metabolic stability models, CYP inhibition etc.) required. Demonstrated experience supporting lead optimization programs, and preclinical candidate characterization to enable studies towards regulatory submissions like IND is necessary.
Strong problem solving and leadership skills are required. In addition, excellent interpersonal and communication skills (written and spoken) are mandatory in order to perform in a matrix team environment.

• Responsible to Plan and maintain EHS Systems & practices on a continuous basis and ensure compliance to all related Legal Norms.
• Periodic Laboratory/ Plant safety audits, Inspection and its reporting.
• Accident / Incident investigation reporting and Record maintenance.
• To prepare job safety analysis and Hazop studies, Risk assessment and risk control.
• To organize Safety Committee meeting, MOM preparation & follow up.
• To Plan EHS trainings, prepare training modules and to Conduct Training / Induction. to all Employee/ New entrants.
• To create awareness on usage of PPEs and ensure to follow the same.
• To manage and ensure implementation of Permit to work system.
• To ensure proper maintenance of safety equipments like safety shower, Fire Extinguishers, Emergency cupboard, Fire Hydrant system, Fire Alarm System and Public Address System.
• To create EHS awareness across the organization and to conduct mock / wet drills periodically to provide experience of handling emergencies.
• Preparation of departmental SOP’s and On-Site/ Off-Site Emergency Plan.
• Liaison with Pollution Control Board, Inspector of Factories and Related Statutory bodies

In-depth experience in OHSAS-18001 and ISO 14001; Knowledge about the current Environmental & Safety Laws, Hazardous waste management, managing Fire Alarm system, Fire Hydrant system. Should be a Effective trouble shooter; Ability to analyze the environment, forecast emergencies to take preventive actions; Excellent Interpersonal Skills; Good written and oral communication skills and Computer proficiency

• The incumbent is expected to design and conduct discovery toxicity studies.
• Capable of developing in vitro/ in vivo predictive models in toxicology.
• Risk assessment of new chemical entities. Statistics and Data analysis
• Expertise in handling, dosing (various routes), clinical signs and bio-sample collection techniques.
• Strong theoretical knowledge in toxicology and allied subjects.

The candidate must possess related industry experience. He/She must have excellent report writing and verbal communication skills and ability to interpret data and communicate effectively with the peers. Candidate is also expected to have management skills in running a toxicology lab in pharmaceutical discovery programs.

• The incumbent is expected to conduct the in vivo and ex vivo safety pharmacology experiments
• Should be a expert in various lab animal handling, anesthesia, canulation of vein and arteries in anaesthetized non-rodent models (eg. rabbit, etc.)
• To record and interpret the results of CNS/CVS/Respiratory system parameters in conscious, anaesthetized in vivo models and ex vivo models
• Should be a expert in handling various instruments related to safety pharmacology
• To perform other related duties as assigned
• Should have a good oral and written communication skill

• Develop and validate biomarker assays by IHC
• Image analysis and validation of analysis methodology
• Calibration and maintenance of equipment with proper documentation.
• Supervise all types of procedures such as accessioning, processing, embedding, cutting and staining of tissue slides.
• Supervise preparation and maintenance of  reagents and supplies
• Responsible for quality control
• Assay trouble-shooting, review and approval of clinical data
• Review and approval assay SOP
• Ability to clearly communicate scientific objectives and project results
• This key personnel should oversee the study from the beginning to the end

• The position requires training in immunohistochemical techniques as part of the doctoral or MD thesis .
• Molecular pathology laboratory hands-on experience  .
• Previous knowledge in biomarker assay development and validation will be added advantage.

•  To be a part of team of VS team for providing husbandry and clinical care to immunecompromised laboratory animals.
• To provide technical support to facility in terms of environmental monitoring, HVAC system, sterilization program and waste disposal program of the facility.
• To performs daily health assessment, diagnostic evaluations, and clinical treatment.
• To ensure compliance of all animal ethical practices at all times as per various requirements like CPCSEA and AAALAC.
• To provide assistance during experimentation including preparation of lab for experiments, administration of general anesthesia and post-experimentation care.
• To provide support on technical procedures for investigative staff as required.  
  To maintain documentation on assigned core functions, following appropriate SOP’s and guidelines. 
• Animal receiving and serum blood collection for further serology evaluation.

• Experience in immunocompromised animal.
• Clear understanding of laboratory animal handling and husbandry practices along with other expertise.
• Excellent communication and sufficient computer and related software skills.

• Husbandry and management of laboratory animal facility.
• Provide and maintain high quality clinical health care and record r all laboratory animals including, the making of clinical diagnoses, managing disease outbreaks and rodent surgery. 
• Participate and coordinate in quality assurance testing to prevent, diagnose, and treat animal disease. 
• Implement training programs for VS animal care technicians, laboratory technicians, and research investigators. 
• Develop and deliver training for all personnel who use animals in research to ensure compliance with applicable regulations and standards.
• Assist the scientific staff with experimental protocol design and animal model development. 
• Provide clinical support such as diagnostic necropsies and technical support to research groups.
• Supervise Veterinary Assistants/Associates as assigned.
• Improve the welfare of animals by complying with IAEC guidelines as well as modern science and ethical principles.
• Perform daily health assessment, diagnostic evaluations, and clinical treatments of laboratory animals.
• Communicate the VS services & capabilities to Scientists

• Requires an understanding of the biology and medicine of laboratory animals; Requires a practical understanding of the use of personal protective equipment to prevent injuries and exposure to zoonotic agents; Knowledge of regulatory requirements and guidelines for the care and use of laboratory animals.

• Responsibilities of the selected candidate will include the timely design of safe, expedient and efficient chemical routes and processes for the synthesis of targeted pharmaceutical intermediates and drug candidates.
• The candidate will also be responsible for the scale-up of these processes to kilo scale and for transitioning such processes to larger scale-up facilities such as pilot plants.

The candidate must possess a strong background in the theory and practice of classical and modern synthetic organic chemistry with a thorough understanding of modern synthetic methods and reaction mechanisms;  The candidate is expected to possess excellent problem solving skills and should have a demonstrated ability to use critical analysis to develop creative and fundamentally sound solutions; Candidate must have expertise in the purification and characterization of organic compounds using chromatography and spectroscopic techniques including NMR, MS and IR spectroscopy;   Good verbal and written communication skills and a desire to work in a collaborative team environment are required; In supervisory and/or project leader roles, the candidate must demonstrate the ability to provide direction, feedback, and assistance to others in an effective manner; Previous experience in process development will be an added advantage.

Research Investigator / Senior Research Investigator

Process Safety Scientist – We are seeking a self-motivated, creative and independent thinking individual to become part of our team of Process R&D scientists. The successful candidate will be responsible for conducting laboratory scale process hazards evaluations using thermal analysis and other analytical techniques in support of the development of processes for the preparation of active pharmaceutical ingredients for BMS’ R&D programs at our Biocon-BMS research center in Bangalore as well as the worldwide manufacturing network.  The successful candidate will manage the hazard evaluation laboratory operations, manage laboratory staff and collaborate with project teams in the design, execution and interpretation of experiments that will enable definition of safe operating conditions and will utilize data in conducting process safety risk assessments. The position requires a Ph.D. in synthetic organic, physical organic chemistry or chemical engineering with 3-5 years of relevant experience.  Postdoctoral experience and knowledge of pharmaceutical process R&D, reaction engineering and application of kinetics and thermodynamics to process safety is a plus. Strong technical writing, oral communication and supervisory skills are required.

The successful candidate will be responsible for timely development of safe and robust processes for the preparation of drug substances in support of drug development activities. Specific unit operations that require investigation in this area include reactions, purification, distillation, crystallization, separation, and drying. Development work includes experimental study of processes in the laboratory and their implementation in the appropriate scale-up facilities.

We are seeking a self-motivated, creative and independent thinking individual to become part of our team of Process R&D scientists. Previous experience in pharmaceutical process R&D is a plus. In addition, the successful candidate will have a strong potential for future leadership responsibilities.