1. Responsibilities of the selected candidate will include the timely design of safe, expedient and efficient chemical routes and processes for the synthesis of targeted pharmaceutical intermediates and drug candidates.
2. The candidate will also be responsible for the scale-up of these processes to kilo scale and for transitioning such processes to larger scale-up facilities such as pilot plants.

1. The candidates will be part of our team of drug discovery scientists involved in lead identification and optimization.
2. Primary responsibilities would include independent design, synthesis, purification and characterization of novel small molecules. Strong working knowledge of synthetic organic chemistry including multi-step synthesis.

1. The successful candidate should have experience in electrophysiology either in academics of research.
2. Hands on experience in working with ePhysics set up and recording and data analysis.

1. Successful candidate will be responsible for supporting/leading electrophysiology requirements for various drug discovery programmes.
2. Demonstrate excellent understanding of Biology, Pharmacology and pathophysiology in one or multiple disease area.
3. Highly competent in multiple technical aspects relevant to own disease area discovery biology.
4. Understands the competitive environment and its implications regarding meeting our goals.
5. Should possess good management, excellent written and oral communication skills. Ability to interact with multi-disciplinary drug discovery teams and contribute to teamwork and teambuilding.
6. Effectively weighs risks, costs and benefits to make rational, objective decisions.
7. Plans, drives and organizes projects in order to achieve goals. Resourceful and foresees hurdles and plans appropriately.
8. Prior working experience in Industrial Drug Discovery is desirable.

1. Crystallization & biophysical characterization of protein
2. Sound knowledge of protein characterization, crystallization of protein-ligand complexes

1. Successful candidate will be responsible for setting up a team of 8-12 Ph.D. and Master level scientists. Would assume responsibility for the completion of studies in multiple therapeutic areas.
2. The individual would be part of the discovery working groups and work with project leaders from different functions to coordinate study designs, implementation and reporting.

1. Successful candidate will be responsible for setting up a team of 8-12 Ph.D. and Master level scientists. Would assume responsibility for the completion of studies in multiple therapeutic areas.
2. The individual would be part of the discovery working groups and work with project leaders from different functions to coordinate study designs, implementation and reporting.

• The candidate must have training as an in vivo Pharmacologist/Biologist with drug discovery experience in one or more of the following therapeutic areas: Neuroscience and Pain/Behavioral Pharmacology.
• Demonstrate excellent understanding of Biology, Pharmacology and pathophysiology in one or multiple disease area. Demonstrates knowledge/ expertise within and outside own disease area.
• Highly competent in multiple technical aspects relevant to own disease area discovery biology.
• Understands the competitive environment and its implications regarding meeting our goals.
• Should possess good management, excellent written and oral communication skills. Ability to interact with multi-disciplinary drug discovery teams and contribute to teamwork and teambuilding.
• Effectively weighs risks, costs and benefits to make rational, objective decisions.
• Plans, drives and organizes projects in order to achieve goals. Resourceful and foresees hurdles and plans appropriately.
• Prior working experience in Industrial Drug Discovery is desirable

1. The successful candidate will be responsible for the implementation and completion of in vivo studies to assess drug action in multiple therapeutic areas.
2. The  individual will also be responsible for data analysis, presentation and report writing.

1. With expert knowledge of Analytical Chemistry and Separation Sciences capable of directing all activities of the Analytical Research and Development in support of Synthesis and Process development and Bio-pharmaceutical support. 
2. Think independently and lead a group of analytical scientists responsible for day to day analytical activities including process scale-up, GLP and GMP, development and validation of methods in support of manufacturing process development of intermediates and APIs. 
3. Responsible for integrating the scientific work of others and provides input on experimental design, data analysis and interpretation.

1. To provide scientific and technical support/guidance to activities involved in identifying developable drug candidates, form selection, physicochemical characterization of new drug candidates, and development of toxicology and Phase I clinical formulations. 
2. To identify the best formulation strategy for rapidly and successfully moving a new compound into Phase I clinical testing and enabling first-in-human formulation production by clinical supplies organization (or third party manufacturer). 
3. To provide coaching and personal development opportunities to staff in scientific as well as managerial areas. 

Knowledge of basic chemistry and pharmaceutical principles in understanding the physicochemical properties of new drug entities and how they relate to the drug’s ultimate in vivo disposition. Hands on experience with routine analytical instrumentation, such as HPLC, DSC, TGA, UV spectrophotometer, etc., and experience with physicochemical characterization and formulation development are desired. Ability to independently plan, design, implement and summarize research experiments and provide scientific leadership. Excellent written and oral communications as well as having good interpersonal skills and the ability to work with teams in a dynamic environment are essential. Hands on computer skills and knowledge of statistics for experimental design and data treatment are important.

Desired Profile

Qualification: M. Pharm/ PhD/ PDF in Pharmaceutics Experience: M.Pharm (3+ years), Ph.D. 1-3 Years Role: Responsible for conducting pre-formulation and early phase formulation studies for drug candidates.

1. To provide scientific and technical support/guidance to activities involved in identifying developable drug candidates, form selection, physicochemical characterization of new drug candidates, and development of toxicology and Phase I clinical formulations. 
2. To identifies the best formulation strategy for rapidly and successfully moving a new compound into Phase I clinical testing and enabling first-in-human formulation production by clinical supplies organization (or third party manufacturer). 
3. To provide coaching and personal development opportunities to staff in scientific as well as managerial areas.

1. Comprehensive understanding of basic pharmaceutics, physical chemistry, organic chemistry, formulation development, drug delivery and biopharmaceutics. 
2. Understanding of the drug discovery process in identifying developable candidates.  Knowledge of scientific principles and practices of other pharmaceutical development functional areas such as Chemical Process Research, Drug Metabolism and Pharmacokinetics, Drug Safety Evaluation, Clinical Pharmacology and Regulatory Sciences. 
3. Industrial research experience in areas of pre-formulation, formulation development, drug delivery, clinical supplies, and CMC regulatory sciences is required. 
4. Demonstrated ability of leading/managing a group of scientists and working with teams in a complex, dynamic environment to effectively achieve objectives. 
5. Ability to utilize in-depth scientific knowledge and experience to develop new or improved solutions to issues encountered during product development. 
6. Must have excellent written and oral communication skills and strong interpersonal and team working skills.

The major responsibility of the selected candidate will be to lead the MAP group, focused on nonclinical pharmacokinetic and metabolism of new chemical entities, in support of various drug discovery programs. He/she will represent the department at all site meetings, and discovery working group meetings, suggest and implement strategies and tactics to address PK/PD/ADME related issues and ultimately enable program decision-making in the selection and advancement of high-quality drug candidates from discovery into development. The incumbent will collaborate with a broad group of scientists in various PCO departments,  and across various disciplines in the Discovery organization. The individual will play a major role in setting group strategy, vision and take a lead in key scientific initiatives.

Hands-on experience and in-depth training in the areas of nonclinical pharmacokinetics (PK), pharmaco-dynamics (PD) and/or drug metabolism are required. These include, but are not limited to, PK and PK/PD study design and data analysis, drug metabolism concepts and assays, enzyme kinetics, etc. Hands-on experience in conducting in vitro and in vivo studies to assess the ADME of discovery compounds (cell culture, metabolic stability models, CYP inhibition etc.) required. Demonstrated experience supporting lead optimization programs, and preclinical candidate characterization to enable studies towards regulatory submissions like IND is necessary.
Strong problem solving and leadership skills are required. In addition, excellent interpersonal and communication skills (written and spoken) are mandatory in order to perform in a matrix team environment.

The major responsibility of the selected candidate will be to lead the Bio-analytical (BAR) and Biotransformation (BTx) groups within PCO. As a leader of the BAR team, the candidate will be responsible for the development, validation, implementation, and troubleshooting of semi-automated multiple component analytical methods for the quantitation of drug candidates in biological matrices. The candidate will be responsible for providing inputs into the design of experimental protocols and bio-analytical procedures for the analysis of samples and troubleshooting of methods and instruments along with the evaluation, interpretation and distribution of bio-analytical results. As a leader of the BTx team, the candidate will focus on exploratory and definitive metabolite identification studies using mass- and radiolabel-based approaches. The candidate should be well-versed with identification of metabolic “soft spots” in new chemical entities and recommend approaches to Medicinal Chemists to modulate metabolic stability. The candidate will represent the department at discovery working group meetings, suggest and implement strategies and tactics to address metabolism and PK-related issues and ultimately enable program decision making in the selection and advancement of high-quality drug candidates into development. The incumbent will collaborate with a broad group of scientists in various PCO departments across various disciplines in the Discovery organization. The individual will play a major role in setting group strategy, vision and take a lead in key scientific initiatives.

The desired candidate should have excellent communication skills and the ability to work in a multi-disciplinary team setting in a fast paced environment. The candidate should have expert knowledge of Bio-analytical Chemistry, Organic Reaction Mechanisms, Separation and Physical Sciences, Mass Spectrometry and a good knowledge of ADMET and Pharmacokinetic principles.
Experience in Bioanalytical quantitation and Metabolite Identification using LC-MS/MS-based methods is required. Demonstrated experience supporting lead optimization programs and preclinical candidate characterization to enable studies towards regulatory submissions like IND is necessary.

Strong problem solving and leadership skills are required. In addition, excellent interpersonal and communication skills (written and spoken) are mandatory in order to perform in a matrix-team environment.

• The incumbent is expected to design and conduct discovery toxicity studies.
• Capable of developing in vitro/ in vivo predictive models in toxicology.
• Risk assessment of new chemical entities. Statistics and Data analysis
• Expertise in handling, dosing (various routes), clinical signs and bio-sample collection techniques.
• Strong theoretical knowledge in toxicology and allied subjects.

The candidate must possess related industry experience. He/She must have excellent report writing and verbal communication skills and ability to interpret data and communicate effectively with the peers. Candidate is also expected to have management skills in running a toxicology lab in pharmaceutical discovery programs.

• The incumbent is expected to conduct the in vivo and ex vivo safety pharmacology experiments
• Should be a expert in various lab animal handling, anesthesia, canulation of vein and arteries in anaesthetized non-rodent models (eg. rabbit, etc.)
• To record and interpret the results of CNS/CVS/Respiratory system parameters in conscious, anaesthetized in vivo models and ex vivo models
• Should be a expert in handling various instruments related to safety pharmacology
• To perform other related duties as assigned
• Should have a good oral and written communication skill

• Primarily perform all types of procedures such as accessioning, processing, embedding, cutting and staining of tissue slides.
• Develop and validate biomarker assays such as IHC, FISH and ability for troubleshooting
• Prepare and maintain reagents and supplies calibrate and maintain equipment with proper documentation.
• Adhere to procedures as directed by Lead Cytotechnologist, Pathologists, and lab head.
• Responsible for accurate quality control
• The candidate needs to work well under supervision, managing their time efficiently and demonstrated flexibility to adapt to changes as processes evolve.
• The desired candidate will be one that proactively participates and engages in the laboratory workflow and environment.

• The senior position requires MLT or MSc degree in life science with 5 years of histology experience.
• Histology tech certification or ASCP preferred.
• Previous molecular pathology laboratory management skills desired.
• Previous knowledge in biomarker assay development and validation will be added advantage.

• To be a part of team of VS team for providing husbandry and clinical care to immunecompromised laboratory animals.
• To provide technical support to facility in terms of environmental monitoring, HVAC system, sterilization program and waste disposal program of the facility.
• To performs daily health assessment, diagnostic evaluations, and clinical treatment.
  
• To ensure compliance of all animal ethical practices at all times as per various requirements like CPCSEA and AAALAC.
• To provides assistance during experimentation including preparation of lab for experiments, administration of general anesthesia and post-experimentation care.
• To provide support on technical procedures for investigative staff as required.  
  To maintain documentation on assigned core functions, following appropriate SOP’s and guidelines. 
• Animal receiving and serum blood collection for further serology evaluation.

• Experience in immunocompromised animal.
• Clear understanding of laboratory animal handling and husbandry practices along with other expertise.
• Excellent communication and sufficient computer and related software skills.

• Responsibilities of the selected candidate will include the timely design of safe, expedient and efficient chemical routes and processes for the synthesis of targeted pharmaceutical intermediates and drug candidates.
• The candidate will also be responsible for the scale-up of these processes to kilo scale and for transitioning such processes to larger scale-up facilities such as pilot plants.

The candidate must possess a strong background in the theory and practice of classical and modern synthetic organic chemistry with a thorough understanding of modern synthetic methods and reaction mechanisms.  The candidate is expected to possess excellent problem solving skills and should have a demonstrated ability to use critical analysis to develop creative and fundamentally sound solutions. Candidate must have expertise in the purification and characterization of organic compounds using chromatography and spectroscopic techniques including NMR, MS and IR spectroscopy.   Good verbal and written communication skills and a desire to work in a collaborative team environment are required. In supervisory and/or project leader roles, the candidate must demonstrate the ability to provide direction, feedback, and assistance to others in an effective manner. Previous experience in process development will be an added advantage.

Process Safety Scientist – We are seeking a self-motivated, creative and independent thinking individual to become part of our team of Process R&D scientists. The successful candidate will be responsible for conducting laboratory scale process hazards evaluations using thermal analysis and other analytical techniques in support of the development of processes for the preparation of active pharmaceutical ingredients for BMS’ R&D programs at our Biocon-BMS research center in Bangalore as well as the worldwide manufacturing network.  The successful candidate will manage the hazard evaluation laboratory operations, manage laboratory staff and collaborate with project teams in the design, execution and interpretation of experiments that will enable definition of safe operating conditions and will utilize data in conducting process safety risk assessments. The position requires a Ph.D. in synthetic organic, physical organic chemistry or chemical engineering with 3-5 years of relevant experience.  Postdoctoral experience and knowledge of pharmaceutical process R&D, reaction engineering and application of kinetics and thermodynamics to process safety is a plus. Strong technical writing, oral communication and supervisory skills are required.

The successful candidate will be responsible for timely development of safe and robust processes for the preparation of drug substances in support of drug development activities. Specific unit operations that require investigation in this area include reactions, purification, distillation, crystallization, separation, and drying. Development work includes experimental study of processes in the laboratory and their implementation in the appropriate scale-up facilities.

We are seeking a self-motivated, creative and independent thinking individual to become part of our team of Process R&D scientists. Previous experience in pharmaceutical process R&D is a plus. In addition, the successful candidate will have a strong potential for future leadership responsibilities.

• The successful candidate will provide hands on support and development for laboratory applications across research at BBRC and should ensure existing tools are utilized to capacity by working with the users to train and integrate local workflows. 
• As a member of a highly effective team, the candidate will share learning’s and experiences, collaborate, troubleshoot and work with other developers within the larger organization to fix any issues. 
• The candidate’s major responsibilities include: a) To represent BBRC needs in requirements gathering exercises. b) Wherever existing applications are not suitable develop small applications to fulfill local requirements.  c) Applications will include among other scenarios, software to capture and analyze data from laboratory instruments and developing simple scripts to drive automated systems. d) support of commercial-off-the-shelf (COTS) applications
• Demonstrated track record in delivering business solutions preferably in a scientific environment
• Certification in Microsoft Office tools a plus

• Strong analytical and communication skills (written and oral) required.
• Strong macro programming skills with the Microsoft Office suite especially Excel required.  Some laboratory instrument programming desired but not required.
• Familiarity with .NET platform, Visual Studio (VB, C#) strongly desired. Basic Oracle database skills required.
• Experience with Sharepoint environment development and usage desired.
• Familiarity with basic scientific concepts (calibration, basic statistics etc.) desired
• Familiarity with applications such as Electronic Laboratory Notebooks desired
• Laboratory experience, desired, but not required
• Independence and creativity, strong organizational and written/verbal communication skills as well as a demonstrated ability to work within an interdisciplinary research team are essential.