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In-vivo Pharmacology

Our In vivo Pharmacology team encompasses broad expertise across multiple therapeutic areas and is supported by a 54,000 Sq. ft AAALAC accredited, GLP-certified vivarium, and experienced scientists with the ability to set up diverse efficacy models as per program/client need. We offer target engagement and efficacy models which are validated with reference compounds and supported by histopathology, biomarker analysis, PK-PD correlation, Imaging and relevant mechanistic assays.


Oncology

  • Subcutaneous tumor xenograft model
  • Orthotopic xenograft model
  • Metastasis models

Metabolic disorders

  • Genetic Models – Zucker Obese Rat (Zucker fa/fa), db/db mice and Zucker Diabetic Fatty (ZDF)
  • Diet Induced – Obesity using C57BL/6 Mice (DIO)
  • STZ Induced – Streptozotocin + Nicotinmide model for T2DM and Streptozotocin Induced T1DM

Inflammation

  • Acute – LPS induced pulmonary inflammation (Rat), Carrageenan induced paw edema (Rat & Mouse), Cytokine Induced Inflammation (Rat & Mouse)
  • Chronic – Carrageenan Air pouch inflammation (Rat), Cotton Pellet Induced Granuloma (Rat), Bleomycin Induced Pulmonary Fibrosis (Rat)

Pain models

  • Chemically Induced Nociception – Acetic acid induced writhing (Rat), Formalin induced tonic pain (Rat & Mouse)
  • Neuropathic Pain – Partial sciatic nerve ligation (PSNL) (Rat), chronic constriction injury (CCI) (Rat), Spinal Nerve Ligation (SNL) (Rat)
  • Inflammatory Pain – Adjuvant (CFA) induced pain

Auto-immune disorders

  • Arthritis – Collagen induced arthritis (CIA) (Rat & Mouse), Adjuvant induced arthritis (AIA) (Rat)
  • Psoriasis – TPA induced epidermal hyperplasia (Mouse), Human Psoriatic Skin Transplanted SCID (Mouse)
  • Colitis – Dextran Sulphate Sodium (DSS) Induced (Ulcerative Colitis) (Mouse), Trinitrobenzene Sulphonate (TNBS) Induced (Chron’s Disease) (Rat & Mouse)
  • Multiple Sclerosis – Experimental Autoimmune Encephalitis (EAE), Chronic Progressive & Relapsing Remitting Models (Mouse)

Osteoarthritis

  • Medial Meniscal Tear (Rat)
  • Anterior Cruciate Ligament Transection (ACLT) (Rat)
  • ACLT + Partial Medial Meniscectomy (Rat)
  • Spontaneous Osteoarthritis (G. Pigs)

Hypersensitivity

  • Type I includes Ovalbumin Induced Dermatitis (Mouse), Oxazolone Induced Dermatitis (Mouse)
  • TYPE IV includes Methylated Bovine Serum Albumin (mBSA) induced paw edema (Mouse), Sheep Red Blood Cell (SRBC) Induced paw edema (Mouse), Acute Graft versus Host reaction (Rat)

Others

  • Critical Limb Ischemia (Mouse)
  • Wound Healing models (Rat) (Excision; Burn; Incision)
  • Carbon tetra-chloride induced liver fibrosis (Rat)
  • Dexamethasone induced Cachexia (Rat)