• Small Molecules
    • Large Molecules
    • Other Drug Modalities
    • SynVent Integrated Drug Discovery
      • SynVent Integrated Drug Discovery

        SynVent is Syngene’s platform for fully integrated therapeutic discovery and development across large and small molecules. 

    • Industries
    • Dedicated Centers
      • Dedicated Centers

        Our Dedicated Centers offer dedicated multi-disciplinary scientific teams, support personnel, and a tailormade ring-fenced and fire-walled infrastructure as per client specifications to support their  R&D  goals

    • Center for Advanced Protein Studies (CAPS)
      • Center for Advanced Protein Studies (CAPS)

        Centre for Advanced Protein Studies [CAPS] is a state-of-the-art advanced national facility located in the Syngene campus, Bangalore.

  • Careers

Acute, Sub-chronic and Chronic Toxicity Studies

Analyzing the toxicity of drugs at different exposure levels

Syngene’s full range of general toxicology services supported by complete toxicokinetic analysis and interpretation services help clients analyze the toxic effects of drugs at various exposure levels. We leverage our in-house expertise on small and large molecule bioanalysis, formulation analysis, clinical and anatomic pathology services, and other disciplines to conduct toxicity studies with integrated endpoints. We deliver faster and cost-efficient results and provide comprehensive and integrated study reports.


Capabilities

Syngene’s experts evaluate the toxicity of drugs and provide dosing recommendations by conducting acute single-dose studies and repeat-dose based sub-acute, sub-chronic, and chronic toxicity studies, involving various species, administration routes, dosage, exposure levels, and methods.

Acute toxicity studies:

  • Single-dose oral, dermal, and inhalation studies
  • Acute inhalation study
  • Local tolerance studies
  • Skin and ocular irritation: Rabbits
  • Mucous membrane irritation: Rabbits
  • Guinea pig maximization studies and local lymph node assay
  • Acute parenteral toxicity studies

Sub-acute toxicity studies:

Repeat dose 7, 14, 21, 28, and 42-day studies

Sub-chronic toxicity studies

Repeat dose 90-day studies

Chronic toxicity studies:

Repeat dose 120 and 180-day studies

 

To download, Please share your details