• Small Molecules
    • Large Molecules
    • Other Drug Modalities
    • SynVent Integrated Drug Discovery
      • SynVent Integrated Drug Discovery

        SynVent is Syngene’s platform for fully integrated therapeutic discovery and development across large and small molecules. 

    • Industries
    • Dedicated Centers
      • Dedicated Centers

        Our Dedicated Centers offer dedicated multi-disciplinary scientific teams, support personnel, and a tailormade ring-fenced and fire-walled infrastructure as per client specifications to support their  R&D  goals

    • Center for Advanced Protein Studies (CAPS)
      • Center for Advanced Protein Studies (CAPS)

        Centre for Advanced Protein Studies [CAPS] is a state-of-the-art advanced national facility located in the Syngene campus, Bangalore.

  • Careers

Developmental and Reproductive Toxicology DART

Evaluating the toxic effects of compounds on reproduction and development

Syngene offers a broad range of customized developmental and reproductive toxicology (DART) services that evaluate the safety of compounds and the effect on reproductive and developmental functions. Our studies help identify pharmaceuticals, biologics, and chemicals that affect fertility and embryonic development, pre-natal and post-natal development, and maternal functions.


Capabilities

Our experts perform various DART studies on rodent and non-rodent species that assess the effect of compounds on the reproductive and nervous systems:

  • Reproductive toxicity: These studies encompass fertility and early embryonic development in rodents, as well as their pre- and post-natal development, and maternal functions. We also conduct multi-generation (one/two) studies on the reproduction toxicity in rats.
  • Developmental toxicity: These studies analyze the adverse effects of a compound’s toxicity in embryo-fetal development in rodents and rabbits.
  • Neurotoxicity: These studies involve observing the toxic effects of a compound or product on motor activity, learning and memory, and neuropathology in rats. The studies also include sensory evaluation tests and functional observational battery (modified Irwin’s tests) in the same species.

 

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