AI-enhanced relay-based drug discovery for optimizing Design-Make-Test-Analyze (DMTA) cycle
SynVantage is Syngene’s platform that enables a continuous and seamless transition between different stages of the Design-Make-Test-Analyze (DMTA) cycle in drug discovery.
The process ensures a relay-based changeover between scientists and other support functions who may be working in shifts in the laboratories at any stage in the drug discovery cycle.
Relay-based approach
In a relay-based model, the ownership for a discovery program lies collectively with a team of scientists. They work collaboratively in a round-the-clock shift system with a just-in-time approach, thereby eliminating inefficiencies and waste. For example, in a small molecule discovery program based on the relay-based model, a team of chemists would work in a coordinated, tandem manner on each chemical reaction step within a synthetic scheme – reagent procurement to reaction set-up, monitoring, and workup, purification, and characterization.
The 24/7 or 24/5 relay model can be configured to cover all three work shifts on a working day with efficient planning and operations. Further, a team leader assigned to this model would ensure seamless handover between two scientists in two different shifts.
Accelerating drug discovery cycle with SynVantage
We believe that our 24/7 or 24/5 relay-based discovery can significantly reduce early discovery timelines by 12 to 18 months, depending on the type of project being handled.
Supporting SynVantage in this task are AI-based predictive algorithms that rapidly and accurately understand the patterns and molecular changes required to predict the optimal compound. This in turn, would result in:
- Optimal utilization of resources
- Faster response to emerging needs for therapeutic discovery
- Faster time-to-market in bringing new therapies to patients in need
SynVantage can be used across Syngene’s drug discovery offerings of Chemistry, Biology, Safety Assessment, and Computational & Data Sciences. All the support functions at Syngene like procurement and stores, purification, analysis, EHS, administration, IT, HR, and operations have also been enabled to complement the relay model.
