Syngene is the expert partner you have been looking for, who can support you from the very start of your protein degradation journey all the way through to the clinic. We have extensive experience working in this space, particularly in the field of heterobifunctional degraders (Linkers – alcohols, halides, acids, amines; Ligands for E3 Ligases -CRBN, VHL, IAP, MDM2). We have supported our clients from early discovery to development to candidate selection, for multiple targets. We are also expanding our capabilities to support programs based on molecular glues, RIBOTACs, LYTACs, and more. Our experience allows us to create a roadmap for your X-TACs research program, supported at each stage by strong supply chain, logistics, program management, and data security teams.
We have run several Protein Degradation programs, and contributed to the discovery of two PROTAC clinical candidates
Client | Mode of degradation | Number of projects |
---|---|---|
US based biotech
| Molecular glues and PROTACs | 7 projects
(enabled advancement of 2 projects to candidate selection) |
UK based large pharma
| PROTACs | Multiple projects |
US based biotech
| RIBOTACs | Multiple projects
|
US based start-up
| Molecular glues | Multiple projects
|
US based biotech
| PROTACs | Multiple projects
|
UK based biotech
| PROTACs | Multiple projects
|
Korea based biotech | PROTACs | One project |
US based VC | PROTACs | One project |
Watch this 3-minute video for insights into the novel modality of Targeted Protein Degradation , and the impact that Syngene is able to deliver to clients working on PROTACs.
Understand more about RNA-targeted small molecule discovery, including current drug discovery approaches and emerging areas of interest, such as RIBOTACs, Epitranscriptomics, and target validation methodologies.
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