Acute, Sub-Chronic and Chronic Toxicity Studies

Analyzing the toxicity of drugs at different exposure levels

Syngene’s full range of general toxicology services supported by complete toxicokinetic analysis and interpretation services help clients analyze the toxic effects of drugs at various exposure levels.

Capabilities

Acute toxicity studies

• Single-dose oral, dermal, and inhalation studies
• Acute inhalation study
• Local tolerance studies
• Skin and ocular irritation: Rabbits
• Mucous membrane irritation: Rabbits
• Guinea pig maximization studies and local lymph node assay
• Acute parenteral toxicity studies

Sub-acute toxicity studies

Repeat dose 7, 14, 21, 28, and 42-day studies

Sub-chronic toxicity studies

Repeat dose 90-day studies

Chronic toxicity studies

Repeat dose 120 and 180-day studies