Scientific Posters

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Choose from a variety of resources to get a better understanding of Syngene’s point of view, expertise or approach to drug discovery, development and manufacturing to ensure client success.

Resource Types

Preparation and in-vitro ADME assays screening for rac-Rotigotine prodrugs towards alleviating PD/restless leg syndrome

Learn how Syngene customized ADME assays to identify rac-Rotigotine prodrugs with enhanced bioavailability, which could be used for treating Parkinson’s disease and restless leg syndrome.

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Viral clearance from conventional to unconventional process steps in Biologics

Learn how viral clearance from unconventional steps can add value to the total viral clearance independently or along with conventional process steps.

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Predicting genotoxicity and carcinogenicity of drugs and chemicals using using OECD QSAR, DEREK Nexus® and TEST

A comparison of in silico prediction of genotoxicity and carcinogenicity of drugs, with the results obtained from curated data in published literature.

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Robust and high-yielding platform process for plasmid DNA production

How Syngene scientists developed a platform process for plasmid DNA production with high titers of > 1 g/L upstream with >25% recovery downstream.

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Process development and scale-up of highly challenging biomolecules

Three case studies on downstream platform process development for antibody fragments, three broadly neutralizing antibodies (bNAbs) against HIV, and a new class of regenerative implant used for treating a degenerative disease.

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Mycoplasma Contamination Detection in Biopharmaceuticals

Presenting impact of Mycoplasma contamination, available testing methods, and why Syngene prefers NAT-based Mycoplasma detection method over other methods.

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Targeted Protein Modulators – Cellular to ADME to PK/PD models and correlations

Presenting the cellular translation to degradation and functional response across different assay platforms using a PROTAC tool SynTAC-ERD, an Estrogen Receptor (ER) degrader.

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In silico toxicity prediction using Derek Nexus for predicting skin sensitization, phototoxicity, hepatotoxicity and in vitro hERG inhib

In silico toxicity evaluation using Derek® Nexus for quicker and cost-effective screening for skin sensitization phototoxicity, hepatotoxicity, and in vitro hERG channel inhibition

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