Advancing mAb manufacturing with customer-centric solutions
Introduction Monoclonal antibodies (mAbs)Â are lab-engineered proteins that mimic the ability of the immune system to neutralize harmful pathogens. Produced by identical immune cells cloned from a single parent cell, these antibodies target a specific antigen with high precision. Their applications span across medicine, treating cancers, autoimmune disorders, and infectious diseases, as well as diagnostics and […]
How AI is Reshaping CRDMOs: Use Cases and Results from Discovery to Manufacturing
In pharma, most attention goes to discovering new molecules and running clinical trials. The work that finally decides whether a program moves on time sits with the CRDMOs, the Contract Research, Development, and Manufacturing Organizations. These partners convert a scientific lead into a robust, compliant, and scalable product. Artificial intelligence and machine learning are now […]
A step-by-step guide for conducting safe and successful bile duct cannulated PK studies
A step-by-step guide for conducting safe and successful bile duct cannulated PK studies Introduction In recent years, the biopharmaceutical industry has increasingly focused on reducing animal testing when conducting safety and efficacy studies for new drugs. Ethical considerations, regulatory guidelines, and advancements in alternative testing methods like artificial intelligence have driven this shift. However, certain […]
Accelerating PROTAC programs to drug the undruggable
Introduction PROTACs are heterobifunctional molecules comprising a ligand targeting a protein of interest (POI) and a ligand targeting an E3 ligase with a connecting linker. This novel design utilizes the organism’s own ubiquitin-proteasome system and induces proximity between E3 ligases and POI, leading to its proteasomal degradation. PROTACs, differ from conventional small molecules in their […]
Rise of the Indian CRO-CDMO: From Cost Arbitrage to Innovation Leadership
From ‘Pharmacy of the World’ to becoming the preferred outsourcing destination for innovative scientific solutions, India’s Life Science industry has seen a dramatic shift. Driving this change is the contract research development manufacturing organization (CRDMO) industry, which witnessed a CAGR of 15% between 2019 and 24, double the global growth rate of 7%–8%. Given this […]
Peptides: A Scientific Revolution in Modern Medicine
The challenge It is a remarkable time for science. GLP-1 (glucagon-like peptide-1) peptides, originally developed for diabetes treatment, have recently been lauded as a potential solution for a variety of unrelated diseases. These peptide drugs have garnered unprecedented attention from patients, scientists, economists, and investors, who view them as a panacea for numerous chronic conditions. […]
Overcoming Analytical Challenges with Chemical Derivatization in LC-MS/MS
Chemical derivatization improves ionization potential, stability, and sensitivity in LC-MS/MS bioanalysis. Learn how Syngene overcomes derivatization challenges.
Long acting injectables accelerating the path to patient wellbeing
Role of Long Acting injectables in Drug Delivery Long-acting injectable (LAI) is a revolutionary drug delivery system that addresses some of the most persistent challenges in treating chronic diseases. These include patient non-compliance in maintaining medication regimen, fluctuating drug levels in the plasma, need for frequent dosing, and more. By delivering therapeutic agents over extended […]
The Dedicated Center- Outsourcing Answer to the Innovation and ROI Challenge in the Biopharmaceutical Industry
Introduction The pharmaceutical industry is facing a sustainability crisis due to dwindling ROI on research and development. Even though the top 20 pharmaceutical companies invested 20.9% of topline revenues into R&D last year, the internal rate of return (IRR) for pharma R&D is already below the cost of capital and is projected to hit zero. […]
How Syngene is implementing Green Chemistry in pharmaceutical development – Design to Delivery
Introduction The UN Climate Change Conference in Glasgow 2021 (COP26) highlighted the responsibility of individuals and companies in tackling the challenges of protecting our planet. With the pharmaceutical industry being a significant contributor to environmental pollution, there is an urgent need to adopt Green Chemistry at all stages of drug development – design to delivery. […]