Helping develop efficient drug dosage forms
Syngene’s formulation development team supports the formulation and process development of drug dosages, by conducting various investigations into the physico-chemical properties of new molecules, compounds, and drugs in different forms. The team utilizes the information gathered from these studies to help clients develop quality products.
Our expert scientists work on a wide range of Pre-Formulation studies that generate useful data for developing stable, bioavailable dosage forms. These studies include:
- Physico-chemical characterization: Our laboratories are well-equipped to test the physico-chemical properties of molecules and compounds according to client requirements. This helps in finding efficient dosage and material stability under multiple conditions. Our studies include solid state characterization, salt and polymorph screening, selection and stability, pH- solubility profile along with pKa values and log P/D determination, pH- solution state stability profile, and solubility in additives. We also calculate intrinsic dissolution rate and perform hygroscopicity studies.
- Powder characterization: We utilize various investigations to identify the physical characteristics and optimization of formulations in powder form. These include particle size distribution analyses, powder flow determination, true density studies, and powder envelop density studies of powders, granules, and roll compacted ribbons. We also perform bulk and tap density determination studies.
- Compatibility studies: Our investigations help select excipients for formulation development. These include drug-drug and drug-excipient compatibility studies, and packaging material compatibility studies.