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In vivo oncology models allow screening of test compounds for anticancer activity againt tumors induced by cancerous cell lines that are derived from either human or mouse tissues. Tumors are grown as subcutaneous, orthotopic or metastatic tumors in mice and rats, invivo. Depending on the type of cancer cells/tissues, the animal model can be of a) Cell-line derived Xenografts (commercially available human cell lines injected in mouse), b) Patient-derived Xenografts (tumor fragments from human patients injected in mice)  or c) Syngeneic (commercially available mouse/ rat cancer cells injected in mouse or rat). 
Specialized cancer models such as humanized mouse, adoptive T-cell transfer and 3D-Spheroid plug models enable enhanced predictivity of clinical effect of immunotherapeutic agents, spontaneous models (APCmin/+) and thereby allowing pre-clinical animal studies to identify the potent immuno-modulatory compounds to maximize their clinical success.  

Syngene’s IVIS Bio-imaging capabilities allow to study not only the biodistribution and disease progression of fluorescence or luminiscence probe-tagged cancerous cells or antibodies injected in mice but also support to study the organ or tissue specific localizations in terms of their accumulation and distribution kinetics.

Cell Line Derived Xenograft (CDX) Models
Patient-Derived Xenografts (PDX) Models
Syngeneic Models
Humanized mouse platform
Adoptive T-cell transfer Models
3D-Spheroid plug Model
IVIS Bio-imaging

Tumor typeCell line
Cell line derived subcutaneous xenograft models in mouse (*+Orthotopic)
AngiosarcomaSVR
BrainU87-MG*
U251
BreastMCF-7
MDA-MB-231*
MDA-MB-468
BladderT24*
5637
TCCSUP
UMC-1*
UMC-14*
KMBC-2
RT-112 (orthotopic)
ColonHCT116*
DLD1
SW480
HT29*
COLO-205
Epidermoid (Skin)A431
GastricN-87
Head & NeckCAL-27
HEp-2
LungA549*
H1975
NCI-H460
NCI-H441
NCI-H23
NCI-H727
H358
NCI-H82
PC-9*
LiverHepG2
SNU-398
JHH-7
MelanomaA375
Multiple MyelomaNCI-H929
MedulloblastomaD283
KidneyACHN
PancreasBX-PC3*
MIA PaCa-2*
ProstateLNCaP
VCap
22Rv1
DU145
Pro-B cell lineBa/F3
OvarianSKOV-3
PA-1
OVCAR-3
OV-90
OsteosarcomaSJSA-1
RetinoblastomaY79
Chronic Myeloid Leukaemia (CML)K562 (Disseminated)
Acute Myeloid Leukaemia (AML)KG-1
MV4-11
Kasumi-3
Burkitt's lymphomaRAJI
Patient derived subcutaneous xenograft models in mouse
Head & NeckPatient-derived tumors
Cell line derived syngeneic models in mouse (*+Orthotopic)
Breast4T1*, EMT6*
E3*
BladderNBT-II* (Rat Model)
ColonCT-26
MC-38
LungLLC
MelanomaB16F10
Humanized mouse subcutaneous model
ProstatePC-3
Adoptive T cell transfer models
LungSHP-77
ColonMC-38 (hCCR2 KI mice)
MC-38 (in B-h4-1BB mice)
3D Spheroid subcutaneous model in mice
MelanomaB16F10
IVIS Bio-imaging
BioluminiscenceBiodistribution of cells/test item tagged with Luciferase
FluorescenceBiodistribution of labelled test item or cells (RFP/GFP/AF647)
Probing growth of orthotopic tumor cells expressing mCherry protein (U251-mCherry)
Biodistribution of mammalian cells or antibodies injected in mice can be can be assessed by Invivo imaging to assess disease development in animals. Test item/antibodies tagged with fluorescence or luminiscence probes support the organ/tissue specificity as well as the kinetics in animals.

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