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Oncology

Oncology

In vivo oncology models allow screening of test compounds for anticancer activity againt tumors induced by cancerous cell lines that are derived from either human or mouse tissues. Tumors are grown as subcutaneous, orthotopic or metastatic tumors in mice and rats, invivo. Depending on the type of cancer cells/tissues, the animal model can be of a) Cell-line derived Xenografts (commercially available human cell lines injected in mouse), b) Patient-derived Xenografts (tumor fragments from human patients injected in mice) or c) Syngeneic (commercially available mouse/ rat cancer cells injected in mouse or rat).

Specialized cancer models such as humanized mouse, adoptive T-cell transfer and 3D-Spheroid plug models enable enhanced predictivity of clinical effect of immunotherapeutic agents, spontaneous models (APCmin/+) and thereby allowing pre-clinical animal studies to identify the potent immuno-modulatory compounds to maximize their clinical success.

Category:

  1. 3D-Spheroid plug Model
  2. Adoptive T-cell transfer Models
  3. Cell Line Derived Xenograft (CDX) Models
  4. Humanized mouse platform
  5. IVIS Bio-imaging
  6. Patient-Derived Xenografts (PDX) Models
  7. Syngeneic Models

List of validated animal models: Download PDF

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