Enhanced productivity of target protein is the requirement of any industry, and more so in the biopharma industry, wherein the productivity cost is high. The biopharmaceutical development team at Syngene works with several clients to optimize their productivity and help them reduce their eventual cost of goods. Towards this effort, an intensified fed-batch process has been developed for mammalian cell culture, which results in a 3 to 4 folds yield enhancement over the conventional fed-batch process. The developed technology is for producing monoclonal antibodies and ensures consistent product quality. The products evaluated showed increased productivity in the range of 7-12 g/L.

In this point of view, we discuss how to use technology to enhance productivity using a high seeding density (HSD) approach. The intensified process through converting the traditional fedbatch process to the HSD process could be the answer to increased upstream productivity.