Chemical Reaction Screening

Syngene’s discovery chemistry services offer an in-house dedicated chemical reaction screening facility that enables rapid go/no-go decisions. This facility supports high throughput screening reactions with state-of-the-art infrastructure.

chemical reaction screening

The chemical reaction screening facility supports the following reactions:

  • Transition metal catalyzed cross-coupling reactions Eg. Buchwald, Suzuki, C(sp2) – C(sp3) coupling, Sonogashira, Ullmann, C-O, C-S coupling reactions
  • Challenging acid-amine coupling, reductive alkylation reactions

The state-of-the-art facility is supported by a dedicated and experienced team of chemists

Mbraun glovebox
Reaction block heaters
Screening platform and Syngene kit
  • Modular box design for easy extension; O2 and H2O < 1ppm, closed loop circulation
  • Negative and positive pressure operation
  • Work can be done in argon or nitrogen atmosphere
  • 12, 24, 48 well plates
  • Can perform 48-microscale reactions in parallel, expandable to 96 reactions
  • Syngene’s own customized kit
  • Reaction suitability: Cross-coupling reactions i.e., – Buchwald, Suzuki, C(sp2) – C(sp3) coupling, Ullmann etc

 

How does it help our customers?
• Rapid Go/No-Go decisions
• Improved turn-around-time (TAT) with project duration reduced by 2-3 weeks
• Overall productivity improvement