Selecting the right preclinical species for screening oral dosage form for PK studies
Learn how Syngene helped a pharma client optimize extended-release drug development by identifying the right animal species as a preclinical model. This decision enhanced PK study accuracy, reduced development time, and supported regulatory success for a once-daily epilepsy treatment.
Accelerating development of a unique molecule to treat lung cancer
Learn how Syngene collaborated with a pharma company to develop the drug substance and drug product for a unique molecule to treat locally advanced lung cancer, including optimizing the process to enable commercial manufacturing of the API.
Developing a stable specialty polymer for use in energy applications: A collaboration with Notark
Learn how Syngene partnered with a global producer of specialty polymers to develop a novel, high-performance polymer for use in sustainable energy generation.
Overcoming analytical challenges with chemical derivatization in LC-MS/MS
Learn about the challenges in chemical derivatization and utilizing LC-MS/MS to detect and quantify trace compounds in complex molecules for supporting bioanalytical studies.
Direct scale up from clone to 2K GMP batches
Learn how Syngene scientists scaled up a clone directly from lab scale to clinical scale and enabled clinical batch manufacturing of the product with an improved titer of >5g/L.
Comprehensive preclinical evaluation of bile acid modulators for paediatric liver disease
Learn how Syngene executed complex preclinical studies, consolidating data across pharmacokinetics, biomarker modulation, and gene expression analysis, and provided comprehensive insights for the client’s development decision on bile acid modulators for paediatric liver disease.
Enabling high product quality, and yield through process optimization for biologics
Learn how Syngene’s expertise in process optimization enabled a biopharma company to achieve high product quality and yield for its PPQ batches, including enabling appropriate scale-up to commercial.
Long acting injectables: Accelerating the path to patient wellbeing
Learn about the various challenges in developing LAIs and the technologies and techniques being used by Syngene to help clients use this transformative drug delivery system to treat chronic diseases.
Developing a green synthesis process for a growth promoter drug for animals
Learn how Syngene developed a green synthesis process for a growth promoter drug for an animal health company that reduced the cE factor and PMI value by 80% while achieving high yield and cost-efficiency.
Reducing variability in gene expression: Bottlenecks and Solutions
Explore challenges in reducing the variability in gene expression in traditional cell line development (CLD) and the power of the transposon system to address these inefficiencies.