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Oncology: List of validated animal models

Oncology: List of validated animal models

Subcutaneous Tumor Xenograft

  • Brain (U87-MG, U251)
  • Breast (MCF-7, MDA-MB-231, MDA-MB-453, SK-BR-3)
  • Bladder (T24, 5637, TCCSUP, HT-1376)
  • Colon (HT29, HCT116, DLD1, SW480, COLO-205, LOVO)
  • Epidermoid (A431)
  • Gastric (N-87)
  • Head & Neck (CAL-27, HEp-2)
  • Lung (A549, H1975, NCI-H460, NCI-H441, NCI-H23, PC-9)
  • Liver (HepG2)
  • Melanoma (A375)
  • Multiple myeloma (NCI-H929)
  • Kidney (ACHN)
  • Pancreas (BX-PC3, MIA PaCa-2)
  • Prostate (DU145, PC-3)
  • Ovary (SKOV-3, PA-1, OVCAR-3, OVCAR-5)
  • Osteosarcoma (SJSA-1)
  • Retinoblastoma (Y79, NCC-RbC-51)
  • Medulloblastoma (D283)

Orthotopic Xenograft model

  • Breast (MDA-MB-231)
  • Colon (HT29, HCT-116)
  • Lung (A549, PC-9)
  • Pancreas (BxPC-3, MIA PaCa-2)
  • Bladder (T24, UMC-1, RT-112)
  • Brain (U87MG)

Syngeneic models

  • B16F10 (Melanoma)
  • LLC (Lewis lung carcinoma)
  • 4T1, E3 (Breast tumor model)
  • CT26, MC-38 (Colon carcinoma)
  • NBT-II (Bladder carcinoma)

Metastasis models

  • CML (K562)
  • Murine melanoma(B16F10)
  • Lung metastasis (A549, PC-9)

Leukemia models

  • CML (K562)
  • HEL
  • AML (KG-1, Kausmi-3)

Human Primary Tissue Xenograft models

  • Head and neck
  • Breast cancer

Humanized model (huNOG-EXL)

  • Prostate (PC-3)
  • Under validation for other
  • Cancer types
  • Lung cancer
  • Melanoma
  • Colon cancer

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