• Small Molecules
      • Discovery
    • Large Molecules
    • Other Drug Modalities
    • SynVent Integrated Drug Discovery
      • SynVent Integrated Drug Discovery

        SynVent is Syngene’s platform for fully integrated therapeutic discovery and development across large and small molecules. 

    • Industries
    • Emerging Biopharma
      • Emerging Biopharma

        Emerging biopharma work at the forefront of science, often venturing into disease areas where little or no real-world data exists to work with or regulatory frameworks to work within.

    • Dedicated Centers
      • Dedicated Centers

        Our Dedicated Centers offer dedicated multi-disciplinary scientific teams, support personnel, and a tailormade ring-fenced and fire-walled infrastructure as per client specifications to support their  R&D  goals

    • Center for Advanced Protein Studies (CAPS)
      • Center for Advanced Protein Studies (CAPS)

        Centre for Advanced Protein Studies [CAPS] is a state-of-the-art advanced national facility located in the Syngene campus, Bangalore.

  • Careers

In-vivo Pharmacology

Our In vivo Pharmacology team encompasses broad expertise across multiple therapeutic areas and is supported by a 54,000 Sq. ft AAALAC accredited, GLP-certified vivarium, and experienced scientists with the ability to set up diverse efficacy models as per program/client need. We offer target engagement and efficacy models which are validated with reference compounds and supported by histopathology, biomarker analysis, PK-PD correlation, Imaging and relevant mechanistic assays.


  • Subcutaneous tumor xenograft model
  • Orthotopic xenograft model
  • Metastasis models

Metabolic disorders

  • Genetic Models – Zucker Obese Rat (Zucker fa/fa), db/db mice and Zucker Diabetic Fatty (ZDF)
  • Diet Induced – Obesity using C57BL/6 Mice (DIO)
  • STZ Induced – Streptozotocin + Nicotinmide model for T2DM and Streptozotocin Induced T1DM


  • Acute – LPS induced pulmonary inflammation (Rat), Carrageenan induced paw edema (Rat & Mouse), Cytokine Induced Inflammation (Rat & Mouse)
  • Chronic – Carrageenan Air pouch inflammation (Rat), Cotton Pellet Induced Granuloma (Rat), Bleomycin Induced Pulmonary Fibrosis (Rat)

Pain models

  • Chemically Induced Nociception – Acetic acid induced writhing (Rat), Formalin induced tonic pain (Rat & Mouse)
  • Neuropathic Pain – Partial sciatic nerve ligation (PSNL) (Rat), chronic constriction injury (CCI) (Rat), Spinal Nerve Ligation (SNL) (Rat)
  • Inflammatory Pain – Adjuvant (CFA) induced pain

Auto-immune disorders

  • Arthritis – Collagen induced arthritis (CIA) (Rat & Mouse), Adjuvant induced arthritis (AIA) (Rat)
  • Psoriasis – TPA induced epidermal hyperplasia (Mouse), Human Psoriatic Skin Transplanted SCID (Mouse)
  • Colitis – Dextran Sulphate Sodium (DSS) Induced (Ulcerative Colitis) (Mouse), Trinitrobenzene Sulphonate (TNBS) Induced (Chron’s Disease) (Rat & Mouse)
  • Multiple Sclerosis – Experimental Autoimmune Encephalitis (EAE), Chronic Progressive & Relapsing Remitting Models (Mouse)


  • Medial Meniscal Tear (Rat)
  • Anterior Cruciate Ligament Transection (ACLT) (Rat)
  • ACLT + Partial Medial Meniscectomy (Rat)
  • Spontaneous Osteoarthritis (G. Pigs)


  • Type I includes Ovalbumin Induced Dermatitis (Mouse), Oxazolone Induced Dermatitis (Mouse)
  • TYPE IV includes Methylated Bovine Serum Albumin (mBSA) induced paw edema (Mouse), Sheep Red Blood Cell (SRBC) Induced paw edema (Mouse), Acute Graft versus Host reaction (Rat)


  • Critical Limb Ischemia (Mouse)
  • Wound Healing models (Rat) (Excision; Burn; Incision)
  • Carbon tetra-chloride induced liver fibrosis (Rat)
  • Dexamethasone induced Cachexia (Rat)

This Website uses Cookies

We use cookies to improve your experience on our site and show you information relevant to your requirements.

To find out more, read our Privacy Policy and Cookies Policy.

To download, Please share your details

To download, Please share your details