Search
Close this search box.
    • Small Molecules
      • Discovery
    • Biologics
    • Other Drug Modalities
    • SynVent Integrated Drug Discovery
      • SynVent Integrated Drug Discovery

        SynVent is Syngene’s platform for fully integrated therapeutic discovery and development across large and small molecules. 

    • Industries
    • Emerging Biopharma
      • Emerging Biopharma

        Emerging biopharma work at the forefront of science, often venturing into disease areas where little or no real-world data exists to work with or regulatory frameworks to work within.

    • Dedicated Centers
      • Dedicated Centers

        Our Dedicated Centers offer dedicated multi-disciplinary scientific teams, support personnel, and a tailormade ring-fenced and fire-walled infrastructure as per client specifications to support their  R&D  goals

    • Center for Advanced Protein Studies (CAPS)
      • Center for Advanced Protein Studies (CAPS)

        Centre for Advanced Protein Studies [CAPS] is a state-of-the-art advanced national facility located in the Syngene campus, Bangalore.

  • Careers
Search
Close this search box.

Bacterial Reverse Mutation Test: AMES Test

Bacterial Reverse Mutation Test: AMES Test

Syngene’s Genetic Toxicology suite has undergone a significant upgrade. Using a state-of-the-art laboratory, our team of expert toxicologists has streamlined the process to deliver AMES test reports on the same day the test is completed. This efficiency level has been made possible by one of India’s first installations of the highly sensitive Sorcerer colony counter equipped with Cyto Study Manager software, which complies with GLP and 21 CFR regulations.

The Cyto Study Manager software merges sophisticated image processing and analysis with sensitive cameras and motorization. This results in a swift and accurate count of bacterial and mammalian colonies for drug development and public health research projects.

Our toxicologists have an in-depth understanding of how to analyze and interpret biological data obtained from the colony counter. Consequently, our customers benefit from expedited IND filings and increased probability of acceptance.

Benefits

  • Shorter turnaround time compared to manual methods 
  • Increased sensitivity  
  • Accurate and robust assay results 
Test model Salmonella typhimurium TA 98, TA 100, TA1535,
TA1537, TA97, TA97a, TA102, and E.coli WP2 UvrA
Assay Controls Negative control: Aqueous and organic solvents
Positive control: Strain-specific positive control
Exposure time 48 – 72 hours
Test item quantity 2.0 grams
Endpoint Growth of revertant colonies
Data delivery Mean number of revertant colonies per plate
• 2-fold increase with vehicle control (TA 98, TA 100, TA97,
TA97a, TA102, and WP2 UvrA)
• 3-fold increase with vehicle control (TA 1535 and TA 1537)
Timeline 2 – 3 Weeks

Your browser does not support this function.

To download, Please share your details

This Website uses Cookies

We use cookies to improve your experience on our site and show you information relevant to your requirements. To find out more, read our Privacy Policy and Cookies Policy.

To view or email, Please share your details view

To download, Please share your details