Syngene’s Genetic Toxicology suite has undergone a significant upgrade. Using a state-of-the-art laboratory, our team of expert toxicologists has streamlined the process to deliver AMES test reports on the same day the test is completed. This efficiency level has been made possible by one of India’s first installations of the highly sensitive Sorcerer colony counter equipped with Cyto Study Manager software, which complies with GLP and 21 CFR regulations.
The Cyto Study Manager software merges sophisticated image processing and analysis with sensitive cameras and motorization. This results in a swift and accurate count of bacterial and mammalian colonies for drug development and public health research projects.
Our toxicologists have an in-depth understanding of how to analyze and interpret biological data obtained from the colony counter from a toxicological perspective. Consequently, our customers benefit from expedited IND filings and increased probability of acceptance.
- Shorter turnaround time compared to manual methods
- Increased sensitivity
- Accurate and robust assay results
|Test model||Salmonella typhimurium TA 98, TA 100, TA1535, TA1537, TA97, TA97a, TA102, and E.coli WP2 UvrA|
|Assay Controls||Negative control: Aqueous and organic solvents
Positive control: Strain-specific positive control
|Exposure time||48 – 72 hours|
|Test item quantity||2.0 grams|
|Endpoint||Growth of revertant colonies|
|Data delivery||Mean number of revertant colonies per plate
• 2-fold increase with vehicle control (TA 98, TA 100, TA97, TA97a, TA102, and WP2 UvrA)
• 3-fold increase with vehicle control (TA 1535 and TA 1537)
|Timeline||2 – 3 Weeks|