The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals usually rodents (rats and mice).
| Test model | Mice and rats |
| Assay controls | Vehicle control: Appropriate vehicle control Positive control: Cyclophosphamide monohydrate |
| Exposure time | 24 and 48 hours |
| Test item quantity | Top dose concentration: Quantity may vary from 2000 mg/kg to 13.2 grams |
| End point | Bone marrow chromosomal aberrations in 200 metaphases |
| Data delivery | Percentage of chromosomal aberration compared with vehicle control mitotic index |
| Timeline | 11 – 12 weeks |
