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Mammalian Bone Marrow Chromosome Aberration Test

Mammalian Bone Marrow Chromosome Aberration Test

The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals usually rodents (rats and mice).

Test model Mice and rats
Assay controls Vehicle control: Appropriate vehicle control
Positive control: Cyclophosphamide monohydrate
Exposure time 24 and 48 hours
Test item quantity Top dose concentration: Quantity may vary from 2000 mg/kg to 13.2 grams
End point Bone marrow chromosomal aberrations in 200 metaphases
Data delivery Percentage of chromosomal aberration compared with vehicle control mitotic index
Timeline 11 – 12 weeks

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