Evaluating the metabolism of test compounds

Syngene offers a suite of validated and efficient cytochrome P450 (CYP) induction assays that provide valuable insights into the metabolism of test compounds. These assays are designed to help clients make informed drug development decisions based on the efficacy and safety profiles of a drug candidate.

Syngene scientists estimate the potential clearance pathways for test compounds through CYP reaction phenotyping methods that use chemical inhibitors in human liver microsomes. The involvement of multiple pathways helps us measure the extent of CYP metabolism-based drug-drug interactions.

Capabilities

Our scientists have vast expertise across all CYP isoforms that enable them to quickly identify strategies to advance a client’s pipeline. Our teams have a strong track record in delivering robust and reliable results, access to best-in-class facilities, and consistently uphold data integrity and client confidentiality in all projects.

The CYP induction assays that we offer include:

• HepG2 cell line (CYP3A4): Reporter gene-based assay
• Human hepatocytes