• Small Molecules
    • Large Molecules
    • Other Drug Modalities
    • SynVent Integrated Drug Discovery
      • SynVent Integrated Drug Discovery

        SynVent is Syngene’s platform for fully integrated therapeutic discovery and development across large and small molecules. 

    • Industries
    • Dedicated Centers
      • Dedicated Centers

        Our Dedicated Centers offer dedicated multi-disciplinary scientific teams, support personnel, and a tailormade ring-fenced and fire-walled infrastructure as per client specifications to support their  R&D  goals

    • Center for Advanced Protein Studies (CAPS)
      • Center for Advanced Protein Studies (CAPS)

        Centre for Advanced Protein Studies [CAPS] is a state-of-the-art advanced national facility located in the Syngene campus, Bangalore.

  • Careers

Permeability and Transporters

Accurately assessing the bioavailability of drug compounds

Syngene offers a comprehensive panel of assays that help accurately gauge a drug’s oral absorption properties, permeability, and transport across cell membranes. We utilize parallel artificial membrane permeability assay (PAMPA) models to assess a drug’s characteristics such as gastrointestinal tract (GIT) absorption and blood-brain barrier (BBB) permeability.

Our offering includes Caco-2 assays that evaluate the intestinal absorption and transport of drug candidates. We also measure the bidirectional permeability across monolayers of Madin-Darby canine kidney (MDCK) cell lines transfected with various genes or cells, helping us predict compounds that are substrates for BBB permeability.

The assays that we offer include:

  • GIT-PAMPA
  • BBB-PAMPA
  • Intrinsic permeability in Caco-2 cell models
  • Breast cancer resistance protein (BCRP)-MDCK-II
  • Multidrug resistance protein (MDR1)-MDCK-II
  • Lilly laboratories cell-porcine kidney (LLC-PK1)-MDR1

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